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KMID : 0858520130170040286
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Journal of the Korean Society of Magnetic Resonance in Medicine
2013 Volume.17 No. 4 p.286 ~ p.293
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A Study of Changes of Inversion Time Effect on Brain Volume of Normal Volunteers
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Kim Ju-Ho
Kim Seong-Hu
Shin Hwa-Seon
Kim Ji-Eun
Na Jae-Boem
Park Ki-Soo
Choi Dae-Seob
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Abstract
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Purpose: The objective of this study was to analyze the brain volume according to the brain image of healthy adults in the 20s taken with different inversion time (TI).
Materials and Methods: Brain images of healthy adults in the 20 s were acquired using magnetization prepared rapid acquisition gradient echo (MPRAGE) pulse sequence with 1.5 mm thickness of pieces and four inversion times (1100 ms, 1000 ms, 900 ms, 800 ms). The acquired brain images were analyzed to measure the volume of white matter (WM), gray matter (GM), intracranial volume (ICV). The statistical difference according to brain volume and gender was analyzed for each TI.
Results: The brain volume calculated using Freesurfer was WM=486.52±48.64 cm3 and GM=646.86±57.12 cm3 in mean when adjusted by mean ICV=1278.94±154.92 cm3. Men's brain volume(WM, GM, ICV) was larger than women's brain volume. In the intrarater reliability test, all of the intraclass correlation coefficients were high (0.992 for WM, 0.988 for GM, and 0.997 for ICV). In the repeated measures analysis of variance, GM and ICV did not show a significant difference at each TI (GM p=0.143, ICV p=0.052), but WM showed a significant (p=0.001). In the linear structure relation analysis, all of the Pearson correlation coefficients were high.
Conclusion: WM, GM, and ICV indicated high reliability and solid linear structure relations, but WM showed significant differences at each TI. The brain volume of healthy adults in the 20s could be used in comparison with that of patients for reference purposes and to predict the structural change of brain. It would be needed to conduct additional studies to examine the contract, SNR, and lesion detection ability according to variable TI.
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KEYWORD
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Freesurfer, Volumetry, Magnetic resonance Imaging (MRI), Inversion time
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